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PhyloGenes (
phylogenes.org) presents precomputed phylogenetic trees of plant gene families along with known functions for individual family members. By displaying experimentally validated gene functions associated to individual genes within a tree, PhyloGenes enables functional inference for genes of uncharacterized function, based on their evolutionary relationships to experimentally studied genes, in a visually traceable manner. For the many families containing genes that have evolved to perform different functions, PhyloGenes also facilitates the study of function evolution. The current PhyloGenes release (version 2.2) includes 40 plant genomes covering a broad taxonomic range and including all major crops, along with 10 non-plant model organisms represented in over 8,000 gene families. Over two-thirds of the families have at least one member with a validated known function as GO terms. To increase the predictive power of PhyloGenes, future work will involve community contribution and emphasize on incorporating new functional annotations of family members across families and subfamilies, and also adding complimentary functional datasets such as gene expression and mutant phenotype
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